calorimetría diferencial de barrido. Polímeros [online]. , vol, n.4, pp ISSN Polímeros. Print version ISSN mediante calorimetría diferencial de barrido convencional y modulada con temperatura: parte II. Polímeros [online]. DSC (Calorimetría Diferencial de Barrido) STA (Termogravimetría Simultánea – Calorimetría de Barrido Diferencial Composites – Polímeros Reforzados.
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Determination of drug content Ten mg of each of the solid dispersion was accurately weighed and dissolved in 10 ml phosphate buffer pH 6. PLGAs bearing carboxylated side chains: The mechanism of the ring-opening polymerization of lactide and glycolide.
DCS: Calorimetría Diferencial de Barrido by Alejandra Campos on Prezi
Polymer Degradation and Stability 98, Evaluation of release kinetic polimros solid dispersions Data obtained from in vitro release studies was fitted to various kinetic equations to find out the mechanism of MET release form polymeric matrix system. Syntheses of poly lactic acid-co-glyclolic acid serial biodegradable polymer materials via direct melt polycondensation and their characterization.
Novel biodegradable polymeric matrix coated cardiovascular stent for controlled drug delivery. Determination of in vitro drug release of solid dispersions. The results revealed that the preparation conditions did not make polymorphic changes or amorphization of drug within the polymer network and higher amount of polymer displayed diluting effect on physicochemical barrdo of drug within prepared dispersions.
Synthetic biodegradable polymers as drug delivery systems for bone morphogenic proteins.
A combination of solid dispersion and extended release is one of the attractive approaches harrido supersaturation of the drugs can be achieved by employing solid dispersion technique. Ho G, Hwang GC. Complexity in biomaterials for tissue engineering.
Functional aliphatic polyester for biomedical and pharmaceutical applications.
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Coupling of molecular orientation with the hydrogen-bond dimensions and H-sites in carboxylic acids. Therefore, in present study, Eudragit RLPO and Eudragit RSPO have been used as retardants to prepare a novel extended release system of highly water soluble medicine metformin barrdo using coevaporation and coprecipitation techniques in order to extend their dissolution rates and to study the influence of type and concentration of Eudragit polymers on release profiles of the developed solid dispersion systems.
The solid dispersion approach is commonly used to improve the dissolution properties of poorly water soluble drugs using hydrophilic polymeric carriers as dispersing agents. One ml of sample was withdrawn from each volumetric flask, suitably diluted and assayed spectrophotometrically at nm.
Metformin HCl and different carriers were taken in different ratios 1: Keeping in mind all these facts, extending or controlling the release of a highly water soluble BCS class I high calorimetrua, high permeability drug seems to be interesting using poli,eros dispersion approach employing lipophilic carriers. No warranty is given about the accuracy aclorimetria the copy.
Effect of PLA grades and morphologies on hydrolytic degradation at composting temperature: Due to the importance of these materials in the following work is presented the study of their absorption properties, interactions and microstructure, by using the analytical techniques of Fourier transform infrared spectroscopy FTIRDifferential Scanning Calorimetry DSC and Microscopy: Controlled release drug delivery systems have the potential of solving these problems.
Concerning the ring-opening polymerization of lactide and cyclic esters by coordination metal catalysts. The precipitates were filtered using qualitative filter paper, spreaded on petri plate and dried to a constant weight.
Análisis térmico I. (DCS). Técnicas de caracterización de polímeros.
This abstract may be abridged. The amount of MET in each sample was computed using calibration curve based on standard solution in phosphate buffer. In phosphate buffer pH 6. For this goal, different types of polymethacrylates Eudragit have been considered. Results of the studies suggested that there were progressive disappearance or changes of prominent peaks in IR, X-ray diffraction and thermotropic drug signals in coevaporates and coprecipitates with increased amount of polymers.
The studies were conducted in triplicate. In vitro dissolution was performed using USP dissolution rate test apparatus I in ml of simulated gastric fluid 0. Journal of Controlled Release A novel and alternative approach to controlled release drug delivery system based on solid dispersion technique. The mechanism of drug release in poly lactic-co-glycolic aci -based drug delivery systems-A review.
Assessment of structural modification and kinetic parameters. Melt-solid polycondensation of lactic acid and its biodegradability.
Development of extended release coevaporates and coprecipitates of promethazine hydrochloride with acrylic polymers: Dissolution rates of different drugs from solid dispersions with Eudragit RS.
Recent developments in ring opening polymerization of lactones for biomedical applications. Materials and methods Materials: Metformin HCl and polymers in two different weight ratios 1: Poly lactic-co-glycolic acid PLGA as biodegradable controlled drug delivery carrier. Determination of in vitro drug release of solid dispersions In vitro dissolution was performed using USP dissolution rate test apparatus I in ml of simulated gastric fluid 0. This phenomenon is typically referred to as ‘burst release’.
Coevaporation method Metformin HCl and different carriers were taken in different ratios 1: These masses were further transferred to 30 ml diethyl ether at 0 o C while being gently stirred. These interactions were made while the molecules were in solution that is when the distances between the molecules were so small that association between the functional groups was possible 9. Bioabsorbable implant material review. The following plots were made: Connective Tissue Research 35, Pharm Res ; 9: Effect of copolymer ratio on hydrolytic degradation of poly lactide-co-glycolide from drug eluting coronary stents.
bbarrido All other chemicals used were of analytical grade and double distilled water was used throughout the studies. J Control Rel ; The drug content was uniform in all solid dispersion systems and was in good agreement with theoretical drug content Table 1.